Our synthesis included six randomized controlled trials with acceptable or high methodological quality (reported in seven articles). Of those, the eligibility of 32 articles was evaluated at the Global Summit and 16 articles were included in our systematic review. We retrieved 4997 citations, removed 1123 duplicates and screened 3874 citations.
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The final risk of bias and evidence tables were reviewed by researchers who attended the Global Summit and 75% (38/50) had to approve the content to reach consensus. We synthesized the evidence from articles with high or acceptable methodological quality according to the Synthesis without Meta-Analysis (SWiM) Guideline. The methodological quality of eligible studies was assessed independently by reviewers using the Scottish Intercollegiate Guidelines Network (SIGN) criteria for randomized controlled trials. Eligible for review were randomized controlled trials published in English.
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We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health, and the Index to Chiropractic Literature from inception to using subject headings specific to each database and free text words relevant to manipulation/manual therapy, effectiveness, prevention, treatment, and non-musculoskeletal disorders. At the summit, participants critically appraised the literature and synthesized the evidence. It was attended by 50 researchers from 8 countries and 28 observers from 18 chiropractic organizations. The Global Summit took place on September 14–15, 2019 in Toronto, Canada. We convened a Global Summit of international scientists to conduct a systematic review of the literature to determine the efficacy and effectiveness of SMT for the primary, secondary and tertiary prevention of non-musculoskeletal disorders. However, the efficacy and effectiveness of these interventions to prevent or treat non-musculoskeletal disorders remain controversial.
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